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Inhibition of HDAC3 Expression Alleviates High-Glucose-Induced Photoreceptor Cell Apoptosis and Oxidative Stress April 30, 2026
CONCLUSION: Our results suggest that HDAC3 is associated with apoptosis and oxidative stress of DR photoreceptors, and the inhibition of HDAC3 can reduce apoptosis and oxidative stress of DR photoreceptors. It is suggested that epigenetic therapy of HDAC3 inhibitors may have therapeutic value in the prevention and treatment of DR.
Insulin resistance, inflammation, oxidative stress and dysregulated WNT/beta-Catenin signaling in polycystic ovary syndrome: A review April 30, 2026
Polycystic ovary syndrome (PCOS) is a multifaceted reproductive and endocrine health issue affecting reproductive aged women, characterized by insulin resistance (IR), chronic low-grade inflammation (LGI), oxidative stress (OS) and dysregulated WNT/β-catenin signaling pathway. Although a part of the involved mechanism in PCOS occurrence is discovered, the exact etiology involving intricate relationships between OS, inflammatory markers […]
Fluoride Damages the Ovary by Inhibiting LKB1-AMPK Signaling to Promote Mitochondrial Injury-Induced Inflammation and Oxidative Stress April 30, 2026
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The role of cyclooxygenase-2 in oxidative stress and inflammation: Implications for poultry health and production April 30, 2026
Oxidative stress and inflammation commonly occur in modern poultry farming, where they are closely linked mechanistically during the progression of disease and adaptation to stressors. This review synthesizes current evidence to outline cyclooxygenase-2 (COX-2) and downstream prostaglandin E2 (PGE₂) signaling via EP receptors as a key molecular nexus that connects excessive reactive oxygen species (ROS) […]
MPC1 regulates endotoxin tolerance of macrophages through mitochondrial oxidative stress resistance April 30, 2026
Increasing evidence highlights the crucial role of endotoxin tolerance in the regulation of the sepsis, yet its underlying mechanisms remain poorly understood. Here, we provide evidence to support a novel role for the mitochondrial pyruvate carrier1 (MPC1)-mediated mitochondrial oxidative stress resistance in regulation of endotoxin tolerance in macrophages. We observed decrease expression of MPC1 in […]