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Ginsenoside Rb1 alleviates overtraining-induced oxidative stress in mouse liver by stimulating mitophagy via Nrf2 pathway May 29, 2026
INTRODUCTION: Moderate exercise induces beneficial adaptive responses in the body, whereas sustained high-intensity exercise without adequate recovery leads to overtraining syndrome (OTS), a pathological condition associated with multiple organ damage, especially liver injury. Currently, safe and effective nutritional interventions for OTS-induced liver injury remain limited. This study aimed to investigate the protective effect of ginsenoside […]
Fructus lycii mitigates oxidative stress in dry age-related macular degeneration models via Nrf2/ARE pathway May 29, 2026
CONCLUSION: FL reduces oxidative stress in an animal model of dry AMD through the Nrf2/ARE signaling pathway and has a protective effect on dry AMD in vitro and in vivo, providing new insights into the therapeutic use of FL for dry AMD.
In silico molecular docking and in vivo evidence of whey protein concentrate-mediated protection against thioacetamide-induced intestinal toxicity in male albino rats via modulation of oxidative stress, inflammation, apoptosis, and fibrosis May 29, 2026
Oxidative stress is a foremost cause in the etiology and progression of numerous illnesses. Thioacetamide (TA) has been demonstrated to promote oxidative stress and has been shown to be harmful in a variety of organs. The antioxidant activity of whey protein concentrate (WPC) has generated a lot of interest since it can help with the […]
Fermented Buckwheat Bee Pollen Attenuates LPS-Induced Acute Inflammation in Mice by Suppressing Oxidative Stress and Inflammatory Response May 29, 2026
This study is aimed at investigating the improvement effects of Lactobacillus plantarum fermentation on buckwheat bee pollen and its efficacy in alleviating lipopolysaccharide (LPS)-induced acute inflammation. Through a combination of scanning electron microscopy observation, chemical composition analysis, in vitro antioxidant evaluation, and in vivo mouse experiments, the structural characteristics, active components, and functional properties of […]
Gallic acid exerts therapeutic effects on sciatica by reducing inflammatory responses through the regulation of NOX4-mediated oxidative stress May 29, 2026
CONCLUSION: GA alleviated sciatica in a rat model, possibly through its ability to promote the polarization of proinflammatory M1 macrophages toward anti-inflammatory M2 macrophages via the regulation of NOX4-mediated oxidative stress.