January 2024

Grapefruit Mock-tail

Leave a Comment / Resilient Eating / Melinda Sherer

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Honey Mint Lemonade

Leave a Comment / Resilient Eating / Melinda Sherer

Honey Mint Lemonade Read More »

Dual effects of progesterone on HaCaT human keratinocytes: apoptosis induction and suppression of oxidative stress and TLR2 expression with potential implications for hyperplastic skin disorders August 19, 2026
CONCLUSIONS: These findings highlight the multifaceted ability of P4 to modulate keratinocyte biology by regulating proliferation, apoptosis, oxidative balance, and inflammatory signaling. Interestingly, these effects occurred despite the absence of specific membrane P4 receptors, suggesting alternative pathways may mediate its actions. Further investigations under inflammatory conditions and in vivo models are warranted to validate these […]
Transcriptomic analysis revealed the protective role of genistein against oxidized fish oil-induced oxidative stress and inflammatory responses in turbot (Scophthalmus maximus) August 19, 2026
INTRODUCTION: Extensive investigations have been conducted across mammalian species to explore the redox-modulating and inflammation-resolving properties of genistein and the mechanisms involved; however, research on the functions of this compound in aquatic species stay insufficient. Therefore, the present research was designed to determine whether oxidative liver injury and inflammatory immune reactions in turbot (Scophthalmus maximus) […]
Coenzyme a-linked neuroprotection: dexpanthenol attenuates neuroinflammation, oxidative stress, and apoptosis to stabilize hippocampal function after ischemia August 19, 2026
Objectives: Neuroinflammation and oxidative stress following cerebral ischemia contribute to neuronal damage and cognitive dysfunction. Dexpanthenol, an antioxidant and neuroprotective derivative of pantothenic acid, may attenuate these pathological processes. This study investigated the neuroprotective effects of dexpanthenol following cerebral ischemia in rats.Methods: Cerebral ischemia was induced using the two-vessel occlusion model, and a single intraperitoneal […]
SUMO2 deficiency impairs endogenous regulation of oxidative stress and apoptosis in myocardial ischemia-reperfusion injury August 19, 2026
INTRODUCTION: Myocardial ischemia-reperfusion injury (MIRI) is a major obstacle in the treatment of myocardial infarction and is closely associated with oxidative stress and cardiomyocyte death. Although endogenous protective mechanisms are activated during ischemic stress, they are often insufficient to prevent injury. SUMOylation is an important post-translational modification involved in cellular stress adaptation, and SUMO2 may […]
Isoprostanes as biomarkers of oxidative stress across human diseases and skin pathologies August 19, 2026
Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) production and antioxidative defenses, is connected with various diseases, including cancer. Isoprostanes (IsoPs), derived from peroxidation of polyunsaturated fatty acids (PUFAs), serve as reliable biomarkers of OS. This review collects knowledge about IsoPs as indicators of OS, focusing on their association with various […]