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Cerebral Ischemia-Reperfusion Injury: Unraveling the Mitophagy-Oxidative Stress Axis for Neuroprotective Strategies March 14, 2026
Cerebral ischemia-reperfusion (I/R) injury is a major pathological contributor to neurological deterioration following ischemic stroke (IS) and remains a critical barrier to effective neuroprotection. Accumulating evidence indicates that cerebral I/R injury is driven not by isolated stress responses but by coordinated and dynamic interactions among multiple cellular pathways. Among these, the bidirectional crosstalk between mitophagy […]
Mitochondrial Haplogroups Influence Mitochondrial Structure and Function, Oxidative Stress, Autophagy, and Lipid Metabolism of Chicken Hepatocytes in Response to Energy Stimulation March 14, 2026
Mitochondria are crucial carriers of maternal effects, and their function is closely related to energy metabolism and disease occurrence. Previous studies have shown that chickens with different mitochondrial haplogroups exhibit differences in production performance, but the underlying mechanism remains unclear. This study investigates the differences in mitochondrial structure and function-related indices between the A and […]
Correction: Ricci et al. SOD-1/2 Involvement in the Antioxidant Molecular Events Occurring upon Complex Magnetic Fields Application in an In Vitro H(2)O(2) Oxidative Stress-Induced Endothelial Cell Model. Int. J. Mol. Sci. 2025, 26, 8600 March 14, 2026
The following reference [24] has been retracted and has to be removed from the original publication [1]:24 [...].
Ellagic Acid Prevents Obesity in High-Fat Diet-Fed Rats by Ameliorating Oxidative Stress via Modulation of the PPARG/STAT3/p-AKT1 Axis March 14, 2026
This study investigated the protective effects and underlying mechanisms of ellagic acid (EA) against high-fat diet (HFD)-induced obesity. Using network pharmacology, STAT3 and AKT1 were identified as pivotal regulatory targets. In vivo experiments demonstrated that EA intervention significantly reduced body weight inducement, improved lipid profiles, and attenuated intestinal oxidative stress and inflammation in HFD-fed rats. […]
Boron Triggers Hepatic Ferroptosis: Unveiling the Dual-Pathogenic Nexus of Oxidative Stress and SLC7A11/GPX4 Dysregulation March 14, 2026
Boron compounds, classified as prohibited food additives due to their high toxicity, persist in pesticides and fertilisers, industrial processes, food supply chains, and consumer goods, perpetuating multisource exposure risks. Chronic ingestion may induce fatal hepatorenal injury; however, mechanistic insights and epidemiological surveillance remain critically lacking amidst sector-wide regulatory gaps. This study employed integrated cellular and […]