June 2021

Redox Health and the CDC Top 12 Killers: #1 Cardiovascular Disease

Leave a Comment / Resilient! The Redox Health Newsletter / Michael Sherer

#1. A Redox Health Model for Cardiovascular Disease “…The common feature of all risk factors of cardiovascular diseases is imbalance between pro- and anti-oxidative factors in the organism with an increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS are key players in normal cardiovascular physiology and signaling, but […]

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Establishment of a mouse model of ovarian oxidative stress induced by hydrogen peroxide November 21, 2024
CONCLUSION: Based on our findings, treatment with 1.50% H(2)O(2) effectively established an oxidative stress model in mice within 1 week. This model serves as a valuable reference for future clinical studies on oxidative stress and reproductive disorders in female animals and humans.
Utilizing the apical-out enteroids in vitro model to investigate intestinal glucose transport, barrier function, oxidative stress, and inflammatory responses in broiler chickens November 21, 2024
INTRODUCTION: Conventional 2D intestinal epithelial cell lines have been widely used in investigating intestinal functions, yet with limitations in recapitulating the in vivo gut physiology of chickens. A recently established chicken enteroid model with apical-out nature and the presence of leukocyte components represents intestinal mucosal functions. The objectives of this study were to 1) evaluate […]
Regulation of oxidative stress enzymes in Candida auris by Dermaseptin: potential implications for antifungal drug discovery November 21, 2024
The emergence of Candida auris poses a significant global health threat due to its high mortality rates and multidrug resistance. The development of new antifungal drugs is essential to effectively combat this pathogen. Antimicrobial peptides, such as Dermaseptin, have demonstrated potent anti-Candida activity. This study aimed to investigate the antifungal activity of Dermaseptin against C. […]
Water Extracts of Moringa oleifera Leaves Alter Oxidative Stress-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells November 21, 2024
Moringa oleifera (MO) has been an important plant for food and traditional medicine in Asian countries, including Indonesia. The leaves of these plants are reported to be rich in antioxidants, vitamins, and micronutrients and have been proven to have nootropic properties. Therefore, we investigated whether MO could provide protective effects on SH-SY5Y neuroblastoma cells exposed […]
Remote limb ischemic pre-conditioning prevents renal Ischemia/reperfusion injury in rats by modulating oxidative stress and TNF-alpha/NF-kappaB/TGF-/betaapelin signaling pathway November 21, 2024
CONCLUSION: Thus, RIPreC can protect against renal dysfunction after renal I/RI via modulation of the TNF-α/NF-κB/TGF-ꞵ/Apelin signaling pathway and strengthening the antioxidant defense system.