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Effect of Formulated Edible Oils From Groundnut and African Walnut Oils on Some Hematological, Inflammation, and Oxidative Stress Markers in High-Fat Diet-Induced Obese Wistar Rats April 21, 2025
The objective of this study was to evaluate the effects of groundnut oil, African walnut oil, and their blends on some biochemical parameters in obese Wistar rats. Obesity was induced with a high-fat diet for 60 days and managed with oils and orlistat for 28 days. The rats were sacrificed on the 29th day, and […]
Oleanolic Acid@SPIONs Alleviates Lipid-Oxidative Stress Injury of Zebrafish Blood Vessels via Regulating the Expression of JNK and MAPK Signaling Pathways in Vascular Endothelial Cells April 21, 2025
CONCLUSION: Therefore, our results confirm that SPIONs can effectively deliver OA for stable release in zebrafish and provide strong evidence that OA@SPION-polyethyleneimine exerts protective effects against oxLDL-induced damage in zebrafish by downregulating the expression of the JNK and MAPK signaling pathways.
The Pathogenesis of Oxidative Stress-Induced Chloasma and Its Therapeutic Implications April 21, 2025
The majority of oral and topical skin-whitening products, as well as chemical peels, are commonly used to treat chloasma, a challenging skin pigmentation disorder. However, the therapeutic efficacy of these treatments often falls short of patients' expectations and is accompanied by notable side effects. Oxidative stress, characterized by an imbalance between oxidation and antioxidation, plays […]
Trehalose induces bladder smooth muscle hypercontractility in mice: involvement of oxidative stress and cellular senescence April 21, 2025
Autophagy, a conserved catabolic process, is critical for cellular homeostasis and its dysregulation has been implicated in a number of conditions including hypertension, obesity and bladder dysfunctions. The autophagy inducer trehalose has shown promise in treating diseases; however, some studies have reported detrimental effects in vascular tissue under health conditions. In the bladder, the effects […]
Mesenchymal stem cells as a therapeutic strategy to combat oxidative stress-mediated neuropathic pain April 21, 2025
Neuropathic pain, a chronic condition resulting from somatosensory system damage, remains a significant clinical challenge due to its complex pathophysiology and inadequate response to traditional therapies. Oxidative stress, characterized by an imbalance between free radicals production and antioxidant defenses, plays a pivotal role in the development and maintenance of neuropathic pain. Mesenchymal stem cells (MSCs) […]