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Sulfated polysaccharides from sea cucumber mitigate acetaminophen-induced acute liver injury in mice via citraconic acid-mediated inhibition of oxidative stress January 13, 2026
Acetaminophen (APAP) is a widely used antipyretic and analgesic drug, but excessive or prolonged use can cause liver injury. Sulfated polysaccharides from sea cucumber (SCSP) exhibit diverse bioactivities; however, their protective role against APAP hepatotoxicity remains unclear. Here, SCSP pretreatment significantly alleviated APAP-induced liver injury in mice, as evidenced by reduced hepatic necrosis, serum transaminases, […]
Flower-shaped ZnO nanoparticles from Lactococcus lactis LAB2: potential selective anti-cancer activity via oxidative stress modulation January 13, 2026
Biosynthesized zinc oxide nanoparticles (ZnO-NP2) produced using Lactococcus lactis culture supernatant demonstrate exceptional selectivity as anticancer agents. These flower-like nanoparticles maintained 96.44% viability in normal HUVEC cells, while reducing the viability of HCT116 and K562 cancer cells to 58.92% and 39.24%, respectively, at a concentration of 0.25 mg/mL. Acridine orange-ethidium bromide staining confirmed dose-dependent apoptosis […]
Venetoclax combined with ML385 overcomes chemotherapy resistance in acute myeloid leukemia by modulating Nrf2/ARE-mediated oxidative stress January 13, 2026
This study aimed to investigate the potential of Venetoclax combined with ML385 to overcome drug resistance in leukemia cells and the related mechanisms. Analysis of Nrf2 expression and its prognostic significance in AML was performed utilizing the GEO and GEPIA2 databases. Bone marrow specimens were collected from newly diagnosed AML patients to evaluate Nrf2 expression […]
Anti-arthritic effect of Helicteres isora L. ethanolic extract via modulation of cytokines and oxidative stress in CFA-induced arthritic rats January 13, 2026
Helicteres isora L. is widely used in traditional medicine for the treatment of gastrointestinal disorders, diabetes, and inflammatory conditions, yet its anti-arthritic potential has not been systematically explored. Given the limitations of conventional rheumatoid arthritis (RA) therapies, evaluation of this plant may provide scientific validation for its ethnomedicinal use against inflammatory diseases. The present study […]
Hesperidin nanoparticle therapy confers renoprotection and antitumor effects in Ehrlich ascites carcinoma via coordinated regulation of oxidative stress, Bax/caspase-3, and NF-kappaB/VEGF pathways January 13, 2026
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